Login
- Dokumenttyp:
- Letter; Letter; Research Support, Non-U.S. Gov't
- Autor(en):
- Grünberg, Mario; Quandt, Dagmar; Cynis, Holger; Demuth, Hans-Ulrich; Kindermann, Andrea; Magdolen, Viktor; Forssmann, Wolf-Georg; Seliger, Barbara; Mägert, Hans-Jürgen
- Titel:
- Kallikrein-related peptidases are activators of the CC chemokine CCL14.
- Abstract:
- Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.
- Zeitschriftentitel:
- Eur J Immunol
- Jahr:
- 2018
- Band / Volume:
- 48
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 1592-1594
- Volltext / DOI:
- doi:10.1002/eji.201747452
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/30028015
- Print-ISSN:
- 0014-2980
- TUM Einrichtung:
- Frauenklinik und Poliklinik
BibTeX