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- Title:
Kallikrein-related peptidases are activators of the CC chemokine CCL14.
- Document type:
- Letter; Letter; Research Support, Non-U.S. Gov't
- Author(s):
- Grünberg, Mario; Quandt, Dagmar; Cynis, Holger; Demuth, Hans-Ulrich; Kindermann, Andrea; Magdolen, Viktor; Forssmann, Wolf-Georg; Seliger, Barbara; Mägert, Hans-Jürgen
- Abstract:
- Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.
- Journal title abbreviation:
- Eur J Immunol
- Year:
- 2018
- Journal volume:
- 48
- Journal issue:
- 9
- Pages contribution:
- 1592-1594
- Fulltext / DOI:
- doi:10.1002/eji.201747452
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30028015
- Print-ISSN:
- 0014-2980
- TUM Institution:
- Frauenklinik und Poliklinik
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