Kallikrein-related peptidases are activators of the CC chemokine CCL14.

Title:: Kallikrein-related peptidases are activators of the CC chemokine CCL14.
Document type:: Letter; Letter; Research Support, Non-U.S. Gov't
Author(s):: Grünberg, Mario; Quandt, Dagmar; Cynis, Holger; Demuth, Hans-Ulrich; Kindermann, Andrea; Magdolen, Viktor; Forssmann, Wolf-Georg; Seliger, Barbara; Mägert, Hans-Jürgen
Abstract:: Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.
Journal title abbreviation:: Eur J Immunol
Year:: 2018
Journal volume:: 48
Journal issue:: 9
Pages contribution:: 1592-1594
Fulltext / DOI:: doi:10.1002/eji.201747452
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30028015
Print-ISSN:: 0014-2980
TUM Institution:: Frauenklinik und Poliklinik
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