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Title:

Activation and activity of glycosylated KLKs 3, 4 and 11.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Guo, Shihui; Briza, Peter; Magdolen, Viktor; Brandstetter, Hans; Goettig, Peter
Abstract:
Human kallikrein-related peptidases 3, 4, 11, and KLK2, the activator of KLK3/PSA, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process. Notably, these KLKs are upregulated in prostate cancer and are used as clinical biomarkers or have been proposed as therapeutic targets. However, this potential awaits a detailed characterization of these proteases. In order to study glycosylated prostatic KLKs resembling the natura...     »
Journal title abbreviation:
Biol Chem
Year:
2018
Journal volume:
399
Journal issue:
9
Pages contribution:
1009-1022
Fulltext / DOI:
doi:10.1515/hsz-2018-0148
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29975661
Print-ISSN:
1431-6730
TUM Institution:
Frauenklinik und Poliklinik
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