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Titel:

Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Haddada, Meriem; Draoui, Hend; Deschamps, Lydia; Walker, Francine; Delaunay, Tiphaine; Brattsand, Maria; Magdolen, Viktor; Darmoul, Dalila
Abstract:
We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of α5/β1/αv/β3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more mali...     »
Zeitschriftentitel:
Biol Chem
Jahr:
2018
Band / Volume:
399
Heft / Issue:
9
Seitenangaben Beitrag:
1099-1105
Volltext / DOI:
doi:10.1515/hsz-2017-0339
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29498930
Print-ISSN:
1431-6730
TUM Einrichtung:
Frauenklinik und Poliklinik
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