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Titel:

Kallikrein-related peptidases are activators of the CC chemokine CCL14.

Dokumenttyp:
Letter; Letter; Research Support, Non-U.S. Gov't
Autor(en):
Grünberg, Mario; Quandt, Dagmar; Cynis, Holger; Demuth, Hans-Ulrich; Kindermann, Andrea; Magdolen, Viktor; Forssmann, Wolf-Georg; Seliger, Barbara; Mägert, Hans-Jürgen
Abstract:
Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.
Zeitschriftentitel:
Eur J Immunol
Jahr:
2018
Band / Volume:
48
Heft / Issue:
9
Seitenangaben Beitrag:
1592-1594
Volltext / DOI:
doi:10.1002/eji.201747452
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30028015
Print-ISSN:
0014-2980
TUM Einrichtung:
Frauenklinik und Poliklinik
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