Kallikrein-related peptidases are activators of the CC chemokine CCL14.

Titel:: Kallikrein-related peptidases are activators of the CC chemokine CCL14.
Dokumenttyp:: Letter; Letter; Research Support, Non-U.S. Gov't
Autor(en):: Grünberg, Mario; Quandt, Dagmar; Cynis, Holger; Demuth, Hans-Ulrich; Kindermann, Andrea; Magdolen, Viktor; Forssmann, Wolf-Georg; Seliger, Barbara; Mägert, Hans-Jürgen
Abstract:: Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.
Zeitschriftentitel:: Eur J Immunol
Jahr:: 2018
Band / Volume:: 48
Heft / Issue:: 9
Seitenangaben Beitrag:: 1592-1594
Volltext / DOI:: doi:10.1002/eji.201747452
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/30028015
Print-ISSN:: 0014-2980
TUM Einrichtung:: Frauenklinik und Poliklinik
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