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Title:

Epstein-Barr virus strain heterogeneity impairs human T-cell immunity.

Document type:
Journal Article
Author(s):
Cirac, Ana; Stützle, Simon; Dieckmeyer, Michael; Adhikary, Dinesh; Moosmann, Andreas; Körber, Nina; Bauer, Tanja; Witter, Klaus; Delecluse, Henri-Jacques; Behrends, Uta; Mautner, Josef
Abstract:
The Epstein-Barr virus (EBV) establishes lifelong infections in > 90% of the human population. Although contained as asymptomatic infection by the immune system in most individuals, EBV is associated with the pathogenesis of approximately 1.5% of all cancers in humans. Some of these EBV-associated tumors have been successfully treated by the infusion of virus-specific T-cell lines. Recent sequence analyses of a large number of viral isolates suggested that distinct EBV strains have evolved in di...     »
Journal title abbreviation:
Cancer Immunol Immunother
Year:
2018
Journal volume:
67
Journal issue:
4
Pages contribution:
663-674
Fulltext / DOI:
doi:10.1007/s00262-018-2118-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29374782
Print-ISSN:
0340-7004
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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