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Titel:

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity.

Dokumenttyp:
journal article
Autor(en):
Norris, Jill M; Lee, Hye-Seung; Frederiksen, Brittni; Erlund, Iris; Uusitalo, Ulla; Yang, Jimin; Lernmark, Åke; Simell, Olli; Toppari, Jorma; Rewers, Marian; Ziegler, Anette-G; She, Jin-Xiong; Onengut-Gumuscu, Suna; Chen, Wei-Min; Rich, Stephen S; Sundvall, Jouko; Akolkar, Beena; Krischer, Jeffrey; Virtanen, Suvi M; Hagopian, William; TEDDY Study Group; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte I; Gesualdo, Pat...     »
Abstract:
We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to...     »
Zeitschriftentitel:
Diabetes
Jahr:
2018
Band / Volume:
67
Heft / Issue:
1
Seitenangaben Beitrag:
146-154
Sprache:
eng
Volltext / DOI:
doi:10.2337/db17-0802
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29061729
Print-ISSN:
0012-1797
TUM Einrichtung:
Klinik und Poliklinik für Kinder- und Jugendmedizin
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