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Titel:

Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome.

Dokumenttyp:
Journal Article; Multicenter Study; Observational Study; Article
Autor(en):
Hennes, Eva-Maria; Baumann, Matthias; Schanda, Kathrin; Anlar, Banu; Bajer-Kornek, Barbara; Blaschek, Astrid; Brantner-Inthaler, Sigrid; Diepold, Katharina; Eisenkölbl, Astrid; Gotwald, Thaddäus; Kuchukhidze, Georgi; Gruber-Sedlmayr, Ursula; Häusler, Martin; Höftberger, Romana; Karenfort, Michael; Klein, Andrea; Koch, Johannes; Kraus, Verena; Lechner, Christian; Leiz, Steffen; Leypoldt, Frank; Mader, Simone; Marquard, Klaus; Poggenburg, Imke; Pohl, Daniela; Pritsch, Martin; Raucherzauner, Markus...     »
Abstract:
To assess the prognostic value of MOG antibodies (abs) in the differential diagnosis of acquired demyelinating syndromes (ADS).Clinical course, MRI, MOG-abs, AQP4-abs, and CSF cells and oligoclonal bands (OCB) in children with ADS and 24 months of follow-up were reviewed in this observational prospective multicenter hospital-based study.Two hundred ten children with ADS were included and diagnosed with acute disseminated encephalomyelitis (ADEM) (n = 60), neuromyelitis optica spectrum disorder (NMOSD) (n = 12), clinically isolated syndrome (CIS) (n = 101), and multiple sclerosis (MS) (n = 37) after the first episode. MOG-abs were predominantly found in ADEM (57%) and less frequently in NMOSD (25%), CIS (25%), or MS (8%). Increased MOG-ab titers were associated with younger age ( = 0.0001), diagnosis of ADEM ( = 0.005), increased CSF cell counts ( = 0.011), and negative OCB ( = 0.012). At 24-month follow-up, 96 children had no further relapses. Thirty-five children developed recurrent non-MS episodes (63% MOG-, 17% AQP4-abs at onset). Seventy-nine children developed MS (4% MOG-abs at onset). Recurrent non-MS episodes were associated with high MOG-ab titers ( = 0.0003) and older age at onset ( = 0.024). MS was predicted by MS-like MRI ( < 0.0001) and OCB ( = 0.007). An MOG-ab cutoff titer >=1:1,280 predicted a non-MS course with a sensitivity of 47% and a specificity of 100% and a recurrent non-MS course with a sensitivity of 46% and a specificity of 86%.Our results show that the presence of MOG-abs strongly depends on the age at disease onset and that high MOG-ab titers were associated with a recurrent non-MS disease course.
Zeitschriftentitel:
Neurology
Jahr:
2017
Band / Volume:
89
Heft / Issue:
9
Seitenangaben Beitrag:
900-908
Sprache:
eng
Volltext / DOI:
doi:10.1212/WNL.0000000000004312
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28768844
Print-ISSN:
0028-3878
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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