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Document type:
journal article 
Author(s):
Köhler, Meike; Beyerlein, Andreas; Vehik, Kendra; Greven, Sonja; Umlauf, Nikolaus; Lernmark, Åke; Hagopian, William A; Rewers, Marian; She, Jin-Xiong; Toppari, Jorma; Akolkar, Beena; Krischer, Jeffrey P; Bonifacio, Ezio; Ziegler, Anette-G; TEDDY study group; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte I; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Norris, Jill; Samper-Imaz, Adela; Steck, An...    »
 
Title:
Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. 
Abstract:
The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models.We investigated data of 613 children from the prospective TEDDY study who were persistent positive fo...    »
 
Journal title abbreviation:
Acta Diabetol 
Year:
2017 
Journal volume:
54 
Journal issue:
11 
Pages contribution:
1009-1017 
Language:
eng 
Print-ISSN:
0940-5429 
TUM Institution:
Klinik und Poliklinik für Kinder- und Jugendmedizin