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Title:

Characterization and clinical enrichment of HLA-C*07:02-restricted Cytomegalovirus-specific CD8+ T cells.

Document type:
Journal Article
Author(s):
Schlott, Fabian; Steubl, Dominik; Ameres, Stefanie; Moosmann, Andreas; Dreher, Stefan; Heemann, Uwe; Hösel, Volker; Busch, Dirk H; Neuenhahn, Michael
Abstract:
Human Cytomegalovirus (CMV) reactivation remains a major source of morbidity in patients after solid organ and hematopoietic stem cell transplantation (HSCT). Adoptive T cell therapy (ACT) with CMV-specific T cells is a promising therapeutic approach for HSCT recipients, but might be counteracted by CMV's immune evasion strategies. HLA-C*07:02 is less susceptible to viral immune evasion suggesting HLA-C*07:02-restricted viral epitopes as promising targets for ACT. For a better understanding of H...     »
Journal title abbreviation:
PLoS ONE
Year:
2018
Journal volume:
13
Journal issue:
2
Pages contribution:
e0193554
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0193554
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29489900
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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