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Title:

Efficient ex vivo delivery of chemically modified messenger RNA using lipofection and magnetofection.

Document type:
Journal Article
Author(s):
Badieyan, Zohreh Sadat; Pasewald, Tamara; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian
Abstract:
Recently, chemically modified mRNA (cmRNA) therapeutics have been the subject of extensive application-oriented research in both academia and industry as a safer alternative for gene and recombinant protein therapies. However, the lack of an efficient delivery system hinders widespread application. Here we used ~100-nm lipoplexes and magnetic lipoplexes that can protect cmRNA from RNases and efficiently deliver it into muscle and fat tissues as well as to the endothelium of the carotid artery. E...     »
Journal title abbreviation:
Biochem Biophys Res Commun
Year:
2017
Journal volume:
482
Journal issue:
4
Pages contribution:
796-801
Language:
eng
Fulltext / DOI:
doi:10.1016/j.bbrc.2016.11.113
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27888105
Print-ISSN:
0006-291X
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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