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Title:

Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases.

Document type:
Journal Article
Author(s):
Geyer, Antonia; Taschauer, Alexander; Alioglu, Fatih; Anton, Martina; Maier, Julia; Drothler, Elisabeth; Simlinger, Manuela; Yavuz, Sümeyye; Sami, Haider; Ogris, Manfred
Abstract:
Local delivery of anticancer agents or gene therapeutics to lung tumors can circumvent side effects or accumulation in non-target organs, but accessibility via the alveolar side of the blood-air barrier remains challenging. Polyplexes based on plasmid and linear polyethylenimine (LPEI) transfect healthy lung tissue when applied intravenously (i.v.) in the mouse, but direct delivery into the lungs results in low transfection of lung tissue. Nevertheless, LPEI could offer the potential to transfec...     »
Journal title abbreviation:
Hum Gene Ther
Year:
2017
Journal volume:
28
Journal issue:
12
Pages contribution:
1202-1213
Language:
eng
Fulltext / DOI:
doi:10.1089/hum.2017.137
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28874076
Print-ISSN:
1043-0342
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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