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Titel:

Modified mRNA for BMP-2 in Combination with Biomaterials Serves as a Transcript-Activated Matrix for Effectively Inducing Osteogenic Pathways in Stem Cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Balmayor, Elizabeth R; Geiger, Johannes P; Koch, Christian; Aneja, Manish K; Van Griensven, Martijn; Rudolph, Carsten; Plank, Christian
Abstract:
Bone regeneration using stem cells and growth factors has disadvantages while needing to use supraphysiological growth factors concentrations. Gene therapy has been proposed as alternative, but also has limitation. Messenger RNA (mRNA)-based transcript therapy is a novel approach that may solve plasmid DNA-based gene therapy limitations. Although much more efficient in delivering genes into the cell, mRNA is unfortunately unstable and immunogenic. However, recent reports indicated that chemical...     »
Zeitschriftentitel:
Stem Cells Dev
Jahr:
2017
Band / Volume:
26
Heft / Issue:
1
Seitenangaben Beitrag:
25-34
Sprache:
eng
Volltext / DOI:
doi:10.1089/scd.2016.0171
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27676276
Print-ISSN:
1547-3287
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Unfallchirurgie
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