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Titel:

Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases.

Dokumenttyp:
Journal Article
Autor(en):
Geyer, Antonia; Taschauer, Alexander; Alioglu, Fatih; Anton, Martina; Maier, Julia; Drothler, Elisabeth; Simlinger, Manuela; Yavuz, Sümeyye; Sami, Haider; Ogris, Manfred
Abstract:
Local delivery of anticancer agents or gene therapeutics to lung tumors can circumvent side effects or accumulation in non-target organs, but accessibility via the alveolar side of the blood-air barrier remains challenging. Polyplexes based on plasmid and linear polyethylenimine (LPEI) transfect healthy lung tissue when applied intravenously (i.v.) in the mouse, but direct delivery into the lungs results in low transfection of lung tissue. Nevertheless, LPEI could offer the potential to transfec...     »
Zeitschriftentitel:
Hum Gene Ther
Jahr:
2017
Band / Volume:
28
Heft / Issue:
12
Seitenangaben Beitrag:
1202-1213
Sprache:
eng
Volltext / DOI:
doi:10.1089/hum.2017.137
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28874076
Print-ISSN:
1043-0342
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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