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Titel:

cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Utzinger, Maximilian; Jarzebinska, Anita; Haag, Nicolas; Schweizer, Martin; Winter, Gerhard; Dohmen, Christian; Rudolph, Carsten; Plank, Christian
Abstract:
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by va...     »
Zeitschriftentitel:
J Control Release
Jahr:
2017
Band / Volume:
249
Seitenangaben Beitrag:
143-149
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jconrel.2017.01.045
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28161466
Print-ISSN:
0168-3659
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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