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Title:

Cholecalciferol 20 000 IU Once Weekly in HIV-Positive Patients with Low Vitamin D Levels: Result from a Cohort Study.

Document type:
Journal Article; 4
Author(s):
Noe, Sebastian; Heldwein, Silke; Pascucchi, Rita; Oldenbüttel, Celia; Wiese, C; Von Krosigk, Ariane; Jägel-Guedes, Eva; Jäger, Hans; Mayer, Wolfgang; Spinner, Christoph D; Wolf, Eva
Abstract:
To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients.Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study.After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level <20 µg/L achieved vitamin D levels >20 µg/L and 42% achieved levels >30 µg/L. Supplemented patients with baseline vitamin D levels <20 µg/L showed a significant risk reduction for hypocalcemia ( P = .006; risk difference: 20.8%) and a significantly lower increase in alkaline phosphatase (AP) compared to those in the nonsubstituted group.The dose of 20 000 IU of cholecalciferol once weekly was found to be safe and effective. Normalization of vitamin D levels within 1 year was observed in 42% to 75% of the patients.
Journal title abbreviation:
J Int Assoc Provid AIDS Care
Year:
2017
Journal volume:
16
Journal issue:
4
Pages contribution:
315-320
Language:
eng
Fulltext / DOI:
doi:10.1177/2325957417702487
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28393662
Print-ISSN:
2325-9574
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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