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Title:

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Document type:
Journal Article; Article
Author(s):
Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Mar...     »
Abstract:
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat obesity and the associated immunometabolic complications. Glucocorticoids are routinely employed for the management of inflammatory diseases, but their pleiotropic nature leads to detrimental metabolic side effects. We developed a glucagon-like peptide-1 (GLP-1)-dexamethasone co-agonist in which GLP-1 selectively delivers dexamethasone to GL...     »
Journal title abbreviation:
Cell Metab
Year:
2017
Journal volume:
26
Journal issue:
4
Pages contribution:
620-632.e6
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cmet.2017.08.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28943448
Print-ISSN:
1550-4131
TUM Institution:
Institut für Humangenetik; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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