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Title:

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms.

Document type:
Journal Article; Article
Author(s):
Molnos, Sophie; Baumbach, Clemens; Wahl, Simone; Müller-Nurasyid, Martina; Strauch, Konstantin; Wang-Sattler, Rui; Waldenberger, Melanie; Meitinger, Thomas; Adamski, Jerzy; Kastenmüller, Gabi; Suhre, Karsten; Peters, Annette; Grallert, Harald; Theis, Fabian J; Gieger, Christian
Abstract:
Genome-wide association studies allow us to understand the genetics of complex diseases. Human metabolism provides information about the disease-causing mechanisms, so it is usual to investigate the associations between genetic variants and metabolite levels. However, only considering genetic variants and their effects on one trait ignores the possible interplay between different "omics" layers. Existing tools only consider single-nucleotide polymorphism (SNP)-SNP interactions, and no practical...     »
Journal title abbreviation:
BMC Bioinformatics
Year:
2017
Journal volume:
18
Journal issue:
1
Pages contribution:
429
Language:
eng
Fulltext / DOI:
doi:10.1186/s12859-017-1838-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28962546
Print-ISSN:
1471-2105
TUM Institution:
Institut für Humangenetik
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