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Title:

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Document type:
Dataset; Journal Article; Article
Author(s):
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M; Dupuis, Josée; Chines, Peter S; Lindgren, Cecilia M; Hartl, Christopher; Jackson, Anne U; Chen, Han; Huyghe, Jeroen R...     »
Abstract:
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in...     »
Journal title abbreviation:
Sci Data
Year:
2017
Journal volume:
4
Pages contribution:
170179
Language:
eng
Fulltext / DOI:
doi:10.1038/sdata.2017.179
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29257133
TUM Institution:
Institut für Humangenetik
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