User: Guest  Login

Title:

Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.

Document type:
Zeitschriftenaufsatz
Author(s):
Wu W, Schecker J, Wuerstle S, Schneider F, Schoenfelder M, Schlegel J
Abstract:
Aldehyde dehydrogenase is a polymorphic enzyme, which responsible for the oxidation of aldehydes. It has been shown that ALDH1A3 is expressed in human glioblastomas and that its expression correlates with a worse prognosis. In our present study ALDH1A3 expression was associated with resistance against Temozolomide (TMZ) treatment and sensitivity could be re-established in ALDH1A3 knockout cells. TMZ treatment at high concentrations diminished ALDH1A3 protein and this downregulation made the tum...     »
Keywords:
ALDH; Aldehyde dehydrogenase; Autophagy; Chemoresistance; Glioblastoma
Dewey Decimal Classification:
610 Medizin und Gesundheit
Journal title:
Cancer Letters
Year:
2018
Year / month:
2018-01
Month:
Jan
Journal issue:
417
Pages contribution:
112-123
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.canlet.2017.12.036
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29306018
Publisher:
Elsevier
Print-ISSN:
0304-3835
E-ISSN:
1872-7980
Impact Factor:
5.851
Semester:
WS 17-18
TUM Institution:
Sportbiologie
 BibTeX