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Titel:

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

Dokumenttyp:
Article
Autor(en):
Cochain, Clément; Vafadarnejad, Ehsan; Arampatzi, Panagiota; Pelisek, Jaroslav; Winkels, Holger; Ley, Klaus; Wolf, Dennis; Saliba, Antoine-Emmanuel; Zernecke, Alma
Abstract:
Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets endowed with specific functions. The precise identity of these subsets is poorly characterized as they have been defined by the expression of a restricted number of markers. Objective: We have applied single-cell RNA sequencing as an unbiased profiling strategy to interrogate and classify aortic macrophage heterogeneity at the single-cell level in atherosclerosis. Method and Results: We performed sing...     »
Zeitschriftentitel:
Circ Res
Jahr:
2018
Band / Volume:
122
Heft / Issue:
12
Seitenangaben Beitrag:
1661-1674
Volltext / DOI:
doi:10.1161/CIRCRESAHA.117.312509
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29545365
Print-ISSN:
0009-7330
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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