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Title:

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Document type:
Zeitschriftenaufsatz
Author(s):
Sun C, De Mello V, Mohamed A, Ortuste Quiroga HP, Garcia-Munoz A, Al Bloshi A, Tremblay AM, von Kriegsheim A, Collie-Duguid E, Vargesson N, Matallanas D, Wackerhage H, Zammit PS.
Abstract:
Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via Tead transcription factors. To investigate their role in skeletal muscle stem cells, we analysed Taz in vivo and ex vivo in comparison to Yap. siRNA knockdown or retroviral-mediated expression of wildtype human or constitutively active TAZ mutants in satellite cells showed that TAZ promoted proliferation, a function shared with YAP. However, at later sta...     »
Keywords:
Hippo Pathway
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Stem Cells
Year:
2017
Journal volume:
35
Year / month:
2017-06
Month:
Jun
Journal issue:
8
Pages contribution:
1958–1972
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1002/stem.2652
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28589555
WWW:
http://onlinelibrary.wiley.com/doi/10.1002/stem.2652/full
Publisher:
Wiley
E-ISSN:
1549-4918
Impact Factor:
5.599
Semester:
SS 17
TUM Institution:
Sportbiologie
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