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Title:

Differential Effects of Surface-Functionalized Zirconium Oxide Nanoparticles on Alveolar Macrophages, Rat Lung, and a Mouse Allergy Model.

Document type:
Journal Article
Author(s):
Vennemann, Antje; Alessandrini, Francesca; Wiemann, Martin
Abstract:
Nanoparticles (NPs) may affect the lung via their chemical composition on the surface. Here, we compared the bioactivity of zirconium oxide (ZrO?) NPs coated with either aminopropilsilane (APTS), tetraoxidecanoic acid (TODS), polyethyleneglycol (PGA), or acrylic acid (Acryl). Supernatants from NPs-treated cultured alveolar macrophages (NR8383) tested for lactate dehydrogenase, glucuronidase, tumor necrosis factor ?, and H?O? formation revealed dose-dependent effects, with only gradual difference...     »
Journal title abbreviation:
Nanomaterials (Basel)
Year:
2017
Journal volume:
7
Journal issue:
9
Language:
eng
Fulltext / DOI:
doi:10.3390/nano7090280
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28925985
Print-ISSN:
2079-4991
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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