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Titel:

Specific Surface Modifications of Silica Nanoparticles Diminish Inflammasome Activation and In Vivo Expression of Selected Inflammatory Genes.

Dokumenttyp:
Journal Article
Autor(en):
Marzaioli, Viviana; Groß, Christina J; Weichenmeier, Ingrid; Schmidt-Weber, Carsten B; Gutermuth, Jan; Groß, Olaf; Alessandrini, Francesca
Abstract:
Silica (SiO?) nanoparticles (NPs) usage includes, but is not limited to, industrial and biomedical applications. Toxic effects of SiO? NPs have been explored either or , assessing different surface modifications to reduce their harmful effects. Here, murine bone marrow-derived dendritic (BMDC) and a mouse model of mild allergic inflammation were used to study inflammasome activation and lung inflammation. Our results showed that SiO? plain NPs induced NACHT, LRR and PYD domains-containing prote...     »
Zeitschriftentitel:
Nanomaterials (Basel)
Jahr:
2017
Band / Volume:
7
Heft / Issue:
11
Sprache:
eng
Volltext / DOI:
doi:10.3390/nano7110355
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29084176
Print-ISSN:
2079-4991
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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