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Title:

Sebum lipids influence macrophage polarization and activation.

Document type:
Journal Article; Article
Author(s):
Lovászi, M; Mattii, M; Eyerich, K; Gácsi, A; Csányi, E; Kovács, D; Rühl, R; Szegedi, A; Kemeny, L; Stahle, M; Zouboulis, C C; Eyerich, S; Tör?csik, D
Abstract:
As lipids are known to regulate macrophage functions, it is reasonable to suppose that a sebocyte-macrophage axis mediated by sebum lipids may exist.To investigate if sebocytes could contribute to the differentiation, polarization and function of macrophages with their secreted lipids.Oil Red O lipid staining and Raman spectroscopy were used to assess the dermal lipid content and penetration. Immunohistochemistry was used to analyse the macrophage subsets. Human peripheral blood monocytes were d...     »
Journal title abbreviation:
Br J Dermatol
Year:
2017
Journal volume:
177
Journal issue:
6
Pages contribution:
1671-1682
Language:
eng
Fulltext / DOI:
doi:10.1111/bjd.15754
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28646583
Print-ISSN:
0007-0963
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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