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Title:

Pro-Inflammatory versus Immunomodulatory Effects of Silver Nanoparticles in the Lung: The Critical Role of Dose, Size and Surface Modification.

Document type:
Journal Article
Author(s):
Alessandrini, Francesca; Vennemann, Antje; Gschwendtner, Silvia; Neumann, Avidan U; Rothballer, Michael; Seher, Tanja; Wimmer, Maria; Kublik, Susanne; Traidl-Hoffmann, Claudia; Schloter, Michael; Wiemann, Martin; Schmidt-Weber, Carsten B
Abstract:
The growing use of silver nanoparticles (Ag-NPs) in consumer products raises concerns about their toxicological potential. The purpose of the study was to investigate the size- and coating-dependent pulmonary toxicity of Ag-NPs in vitro and in vivo, using an ovalbumin (OVA)-mouse allergy model. Supernatants from (5.6-45 µg/mL) Ag50-PVP, Ag200-PVP or Ag50-citrate-treated NR8383 alveolar macrophages were tested for lactate dehydrogenase and glucuronidase activity, tumor necrosis factor (TNF)-? rel...     »
Journal title abbreviation:
Nanomaterials (Basel)
Year:
2017
Journal volume:
7
Journal issue:
10
Language:
eng
Fulltext / DOI:
doi:10.3390/nano7100300
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28961222
Print-ISSN:
2079-4991
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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