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Titel:

Dietary sugars, not lipids, drive hypothalamic inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Gao, Yuanqing; Bielohuby, Maximilian; Fleming, Thomas; Grabner, Gernot F; Foppen, Ewout; Bernhard, Wagner; Guzmán-Ruiz, Mara; Layritz, Clarita; Legutko, Beata; Zinser, Erwin; García-Cáceres, Cristina; Buijs, Ruud M; Woods, Stephen C; Kalsbeek, Andries; Seeley, Randy J; Nawroth, Peter P; Bidlingmaier, Martin; Tschöp, Matthias H; Yi, Chun-Xia
Abstract:
The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate, with respect to the hypothalamic inflammatory response and the consequent impact on hypothalamic control of energy homeostasis is yet not clear.We dissected the different effects of high-carbohydrate high-fat (HCHF) diets and low-carbohydrate high-fat (LCHF) d...     »
Zeitschriftentitel:
Mol Metab
Jahr:
2017
Band / Volume:
6
Heft / Issue:
8
Seitenangaben Beitrag:
897-908
Volltext / DOI:
doi:10.1016/j.molmet.2017.06.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28752053
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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