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Title:

Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber.

Document type:
Journal Article; Article
Author(s):
Karttunen, Marja J; Czopka, Tim; Goedhart, Marieke; Early, Jason J; Lyons, David A
Abstract:
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately, the process of remyelination often fails, particularly with ageing. Even when remyelination occurs, it is characterised by the regeneration of myelin sheaths that are abnormally thin and short. This imperfect remyelination is likely to have imp...     »
Journal title abbreviation:
PLoS ONE
Year:
2017
Journal volume:
12
Journal issue:
5
Pages contribution:
e0178058
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0178058
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28542521
Print-ISSN:
1932-6203
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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