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Title:

Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload.

Document type:
Journal Article
Author(s):
Toischer, Karl; Zhu, Wuqiang; Hünlich, Mark; Mohamed, Belal A; Khadjeh, Sara; Reuter, Sean P; Schäfer, Katrin; Ramanujam, Deepak; Engelhardt, Stefan; Field, Loren J; Hasenfuss, Gerd
Abstract:
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2-expressing and WT mice. Although cyclin D2 expression dramatically improved survival following TAC, it did not confer a survival advantag...     »
Journal title abbreviation:
J Clin Invest
Year:
2017
Journal volume:
127
Journal issue:
12
Pages contribution:
4285-4296
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI81870
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29083322
Print-ISSN:
0021-9738
TUM Institution:
Institut für Pharmakologie und Toxikologie
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