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Document type:
Comparative Study; Journal Article; Comparative Study; Journal Article 
Author(s):
Mak, Stefanie; Sun, Ruoyu; Schmalenberg, Michael; Peters, Carsten; Luppa, Peter B 
Title:
Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs. 
Abstract:
Analysis of membrane proteins is still inadequately represented in diagnostics despite their importance as drug targets and biomarkers. One main reason is the difficult handling caused by their insolubility in aqueous buffer solutions. The nanodisc technology was developed to circumvent this challenge and enables analysis of membrane proteins with standard research methods. However, existing nanodisc generation protocols rely on time-consuming membrane isolation and protein purification from ove...    »
 
Journal title abbreviation:
Biochem J 
Year:
2017 
Journal volume:
474 
Journal issue:
Pages contribution:
1361-1371 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0264-6021 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie