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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article 
Author(s):
Bergmann, Hanna; Roth, Susanne; Pechloff, Konstanze; Kiss, Elina A; Kuhn, Sabine; Heikenwälder, Mathias; Diefenbach, Andreas; Greten, Florian R; Ruland, Jürgen 
Title:
Card9-dependent IL-1? regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer. 
Abstract:
Inflammatory bowel diseases (IBD) are key risk factors for the development of colorectal cancer, but the mechanisms that link intestinal inflammation with carcinogenesis are insufficiently understood. Card9 is a myeloid cell-specific signaling protein that regulates inflammatory responses downstream of various pattern recognition receptors and which cooperates with the inflammasomes for IL-1? production. Because polymorphisms in Card9 were recurrently associated with human IBD, we investigated t...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2017 
Journal volume:
47 
Journal issue:
Pages contribution:
1342-1353 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie