User: Guest  Login
Document type:
Journal Article; Journal Article 
Author(s):
Sagar, Divya; Singh, Narendra P; Ginwala, Rashida; Huang, Xiaofang; Philip, Ramila; Nagarkatti, Mitzi; Nagarkatti, Prakash; Neumann, Konstantin; Ruland, Jürgen; Andrews, Allison M; Ramirez, Servio H; Khan, Zafar K; Jain, Pooja 
Title:
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity. 
Abstract:
The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we identified functions of one C-type lectin receptor, CLEC12A, in facilitating DC binding and transmigration across the BBB in response to CCL2 chemotaxis. To test function of CLEC12A in an animal model of...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
2707 
Language:
eng 
Print-ISSN:
2045-2322 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie