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Titel:

Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs.

Dokumenttyp:
Comparative Study; Journal Article; Comparative Study; Journal Article
Autor(en):
Mak, Stefanie; Sun, Ruoyu; Schmalenberg, Michael; Peters, Carsten; Luppa, Peter B
Abstract:
Analysis of membrane proteins is still inadequately represented in diagnostics despite their importance as drug targets and biomarkers. One main reason is the difficult handling caused by their insolubility in aqueous buffer solutions. The nanodisc technology was developed to circumvent this challenge and enables analysis of membrane proteins with standard research methods. However, existing nanodisc generation protocols rely on time-consuming membrane isolation and protein purification from ove...     »
Zeitschriftentitel:
Biochem J
Jahr:
2017
Band / Volume:
474
Heft / Issue:
8
Seitenangaben Beitrag:
1361-1371
Sprache:
eng
Volltext / DOI:
doi:10.1042/BCJ20161110
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28246334
Print-ISSN:
0264-6021
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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