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Titel:

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.

Dokumenttyp:
Journal Article; Journal Article
Autor(en):
Schneider, Katharina S; Groß, Christina J; Dreier, Roland F; Saller, Benedikt S; Mishra, Ritu; Gorka, Oliver; Heilig, Rosalie; Meunier, Etienne; Dick, Mathias S; ?ikovi?, Tamara; Sodenkamp, Jan; Médard, Guillaume; Naumann, Ronald; Ruland, Jürgen; Kuster, Bernhard; Broz, Petr; Groß, Olaf
Abstract:
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1? and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzymatically inactive caspase-1, we provide genetic evidence that caspase-1 protease activity is required for canonical IL-1 secretion, pyroptosis, and inflammasome-mediated immunity. In caspase-1-deficient cells, caspase-8 can be activated at the inflamm...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2017
Band / Volume:
21
Heft / Issue:
13
Seitenangaben Beitrag:
3846-3859
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.celrep.2017.12.018
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29281832
Print-ISSN:
2211-1247
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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