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Title:

Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.

Document type:
Journal Article; Article
Author(s):
Schieck, Maximilian; Schouten, Jan P; Michel, Sven; Suttner, Kathrin; Toncheva, Antoaneta A; Gaertner, Vincent D; Illig, Thomas; Lipinski, Simone; Franke, Andre; Klintschar, Michael; Kalayci, Omer; Sahiner, Umit M; Birben, Esra; Melén, Erik; Pershagen, Göran; Freidin, Maxim B; Ogorodova, Ludmila M; Granell, Raquel; Henderson, John; Brunekreef, Bert; Smit, Henriette A; Vogelberg, Christian; von Berg, Andrea; Bufe, Albrecht; Heinzmann, Andrea; Laub, Otto; Rietschel, Ernst; Simma, Burkhard; Genunei...     »
Abstract:
Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood.We analyzed whether and how genetic factors contribute to sex-specific predisposition to childhood-onset asthma.Interactions between sex and polymorphisms on childhood asthma risk were evaluated in the Multicentre Asthma Genetics in Childhood Study (MAGICS)/Phase II International Study of Asthma and Allergies in Childhoo...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2016
Journal volume:
138
Journal issue:
2
Pages contribution:
421-31
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2015.12.1305
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26906082
Print-ISSN:
0091-6749
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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