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Titel:

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Dokumenttyp:
Journal Article; Article
Autor(en):
Müller, Anne; Niederstadt, Lars; Jonas, Wenke; Yi, Chun-Xia; Meyer, Franziska; Wiedmer, Petra; Fischer, Jana; Grötzinger, Carsten; Schürmann, Annette; Tschöp, Matthias; Kleinau, Gunnar; Grüters, Annette; Krude, Heiko; Biebermann, Heike
Abstract:
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs), melanocortin receptor 4 (MC4R), and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex...     »
Zeitschriftentitel:
Front Endocrinol (Lausanne)
Jahr:
2016
Band / Volume:
7
Seitenangaben Beitrag:
109
Volltext / DOI:
doi:10.3389/fendo.2016.00109
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27551276
Print-ISSN:
1664-2392
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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