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Document type:
Journal Article; Article 
Author(s):
Brill, Monika S; Kleele, Tatjana; Ruschkies, Laura; Wang, Mengzhe; Marahori, Natalia A; Reuter, Miriam S; Hausrat, Torben J; Weigand, Emily; Fisher, Matthew; Ahles, Andrea; Engelhardt, Stefan; Bishop, Derron L; Kneussel, Matthias; Misgeld, Thomas 
Title:
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. 
Abstract:
Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss o...    »
 
Journal title abbreviation:
Neuron 
Year:
2016 
Journal volume:
92 
Journal issue:
Pages contribution:
845-856 
Language:
eng 
Print-ISSN:
0896-6273 
TUM Institution:
Institut für Pharmakologie und Toxikologie; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)