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- Titel:
Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.
- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't
- Autor(en):
- Telieps, Tanja; Köhler, Meike; Treise, Irina; Foertsch, Katharina; Adler, Thure; Busch, Dirk H; Hrab? de Angelis, Martin; Verschoor, Admar; Adler, Kerstin; Bonifacio, Ezio; Ziegler, Anette-Gabriele
- Abstract:
- Immune phenotyping provides insight into disease pathogenesis and prognostic markers. Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD (n = 58) and NOR (n = 22) mice. NOD mice had higher trajectories of insulin autoantibodies, CD4(+) and CD8(+) T lymphocytes, B lymphocytes, IgD(+)IgM(-) B lymphocytes, and NK cells and lower trajectories of CD4(+)CD25(+) T lymphocytes, IgM(+) B lymphocytes, granulocytes, and monocytes than NOR mice (all p < 0.001). Of these, only the increased IAA trajectory was observed in NOD mice that developed diabetes as compared to NOD mice that remained diabetes-free. Therefore, the profound differences in peripheral blood leukocyte proportions observed between the diabetes-prone NOD mice and the diabetes-resistant mice do not explain the variation in diabetes development within NOD mice and do not provide markers for diabetes prediction in this model.
- Zeitschriftentitel:
- J Diabetes Res
- Jahr:
- 2016
- Band / Volume:
- 2016
- Seitenangaben Beitrag:
- 4208156
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1155/2016/4208156
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/26966692
- Print-ISSN:
- 2314-6745
- TUM Einrichtung:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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