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Title:

Age-related myelin degradation burdens the clearance function of microglia during aging.

Document type:
journal article
Author(s):
Safaiyan, Shima; Kannaiyan, Nirmal; Snaidero, Nicolas; Brioschi, Simone; Biber, Knut; Yona, Simon; Edinger, Aimee L; Jung, Steffen; Rossner, Moritz J; Simons, Mikael
Abstract:
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunc...     »
Journal title abbreviation:
Nat Neurosci
Year:
2016
Journal volume:
19
Journal issue:
8
Pages contribution:
995-8
Language:
eng
Fulltext / DOI:
doi:10.1038/nn.4325
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27294511
Print-ISSN:
1097-6256
TUM Institution:
Institut für Zellbiologie des Nervensystems
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