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Title:

SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.

Document type:
journal article
Author(s):
Santarelli, S; Wagner, K V; Labermaier, C; Uribe, A; Dournes, C; Balsevich, G; Hartmann, J; Masana, M; Holsboer, F; Chen, A; Müller, M B; Schmidt, M V
Abstract:
Major depression is a multifactorial disease, involving both environmental and genetic risk factors. Recently, SLC6A15 - a neutral amino acid transporter mainly expressed in neurons - was proposed as a new candidate gene for major depression and stress vulnerability. Risk allele carriers for a single nucleotide polymorphism (SNP) in a SLC6A15 regulatory region display altered hippocampal volume, glutamate levels, and hypothalamus-pituitary-adrenal axis activity, all markers associated with major...     »
Journal title abbreviation:
Stress
Year:
2016
Journal volume:
19
Journal issue:
1
Pages contribution:
83-90
Language:
eng
Fulltext / DOI:
doi:10.3109/10253890.2015.1105211
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26585320
Print-ISSN:
1025-3890
TUM Institution:
Institut für Neurowissenschaften
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