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Titel:

Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain.

Dokumenttyp:
Journal Article; Article
Autor(en):
Antyborzec, Inga; O'Leary, Valerie B; Dolly, James O; Ovsepian, Saak V
Abstract:
Basal forebrain cholinergic neurons (BFCNs) are one of the most affected neuronal types in Alzheimer's disease (AD), with their extensive loss documented at late stages of the pathology. While discriminatory provision of neuroprotective agents and trophic factors to these cells is thought to be of substantial therapeutic potential, the intricate topography and structure of the forebrain cholinergic system imposes a major challenge. To overcome this, we took advantage of the physiological enrichm...     »
Zeitschriftentitel:
Neurotherapeutics
Jahr:
2016
Band / Volume:
13
Heft / Issue:
4
Seitenangaben Beitrag:
859-870
Sprache:
eng
Volltext / DOI:
doi:10.1007/s13311-016-0445-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27220617
Print-ISSN:
1933-7213
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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