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Titel:

Low-dose fludarabine with or without darbepoetin alfa in patients with chronic lymphocytic leukemia and comorbidity: primary results of the CLL9 trial of the German CLL Study Group.

Dokumenttyp:
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Article
Autor(en):
Goede, Valentin; Busch, Raymonde; Bahlo, Jasmin; Chataline, Viktoria; Kremers, Stephan; Müller, Lothar; Reschke, Daniel; Schlag, Rudolf; Schmidt, Burkhard; Vehling-Kaiser, Ursula; Wedding, Ulrich; Stilgenbauer, Stefan; Hallek, Michael
Abstract:
This study was planned as a phase 3 trial to investigate low-dose fludarabine with or without darbepoetin alfa in older patients with previously untreated or treated chronic lymphocytic leukemia (CLL) and comorbidity. Due to slow recruitment, the study was terminated prematurely after accrual of 97 patients who, on average, were 74 years old and had a cumulative illness rating scale (CIRS) total score of 5. We report toxicity and efficacy of the study treatment. Grade 3-5 neutropenia and infecti...     »
Zeitschriftentitel:
Leuk Lymphoma
Jahr:
2016
Band / Volume:
57
Heft / Issue:
3
Seitenangaben Beitrag:
596-603
Sprache:
eng
Volltext / DOI:
doi:10.3109/10428194.2015.1079314
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26293380
Print-ISSN:
1042-8194
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie
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