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Titel:

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.

Dokumenttyp:
Journal Article; Article
Autor(en):
Regn, Michael; Laggerbauer, Bernhard; Jentzsch, Claudia; Ramanujam, Deepak; Ahles, Andrea; Sichler, Sonja; Calzada-Wack, Julia; Koenen, Rory R; Braun, Attila; Nieswandt, Bernhard; Engelhardt, Stefan
Abstract:
A key response of the myocardium to stress is the secretion of factors with paracrine or endocrine function. Intriguing in this respect is peptidase inhibitor 16 (PI16), a member of the CAP family of proteins which we found to be highly upregulated in cardiac disease. Up to this point, the mechanism of action and physiological function of PI16 remained elusive. Here, we show that PI16 is predominantly expressed by cardiac fibroblasts, which expose PI16 to the interstitium via a glycophosphatidyl...     »
Zeitschriftentitel:
J Mol Cell Cardiol
Jahr:
2016
Band / Volume:
99
Seitenangaben Beitrag:
57-64
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.yjmcc.2016.08.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27539859
Print-ISSN:
0022-2828
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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