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Title:

Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior.

Document type:
Journal Article; Article
Author(s):
Kim, Seonil; Pick, Joseph E; Abera, Sinedu; Khatri, Latika; Ferreira, Danielle D P; Sathler, Matheus F; Morison, Sage L; Hofmann, Franz; Ziff, Edward B
Abstract:
Phosphorylation of GluA1, a subunit of AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control of synaptic transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, and cGKII knockout (KO) affects GluA1 phosphorylation and alters animal behavior. Notably, GluA1 phosphorylation in the KO hippocampus is increased as a functional compensation for gene deletion, while such compensation is absent in the prefrontal cortex. Thus, there are brain regio...     »
Journal title abbreviation:
Learn Mem
Year:
2016
Journal volume:
23
Journal issue:
8
Pages contribution:
435-41
Language:
eng
Fulltext / DOI:
doi:10.1101/lm.042960.116
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27421896
Print-ISSN:
1072-0502
TUM Institution:
Institut für Pharmakologie und Toxikologie
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