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Title:

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.

Document type:
Journal Article; Article
Author(s):
Regn, Michael; Laggerbauer, Bernhard; Jentzsch, Claudia; Ramanujam, Deepak; Ahles, Andrea; Sichler, Sonja; Calzada-Wack, Julia; Koenen, Rory R; Braun, Attila; Nieswandt, Bernhard; Engelhardt, Stefan
Abstract:
A key response of the myocardium to stress is the secretion of factors with paracrine or endocrine function. Intriguing in this respect is peptidase inhibitor 16 (PI16), a member of the CAP family of proteins which we found to be highly upregulated in cardiac disease. Up to this point, the mechanism of action and physiological function of PI16 remained elusive. Here, we show that PI16 is predominantly expressed by cardiac fibroblasts, which expose PI16 to the interstitium via a glycophosphatidyl...     »
Journal title abbreviation:
J Mol Cell Cardiol
Year:
2016
Journal volume:
99
Pages contribution:
57-64
Language:
eng
Fulltext / DOI:
doi:10.1016/j.yjmcc.2016.08.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27539859
Print-ISSN:
0022-2828
TUM Institution:
Institut für Pharmakologie und Toxikologie
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