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Title:

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.

Document type:
journal article
Author(s):
Höckendorf, Ulrike; Yabal, Monica; Herold, Tobias; Munkhbaatar, Enkhtsetseg; Rott, Stephanie; Jilg, Stefanie; Kauschinger, Johanna; Magnani, Giovanni; Reisinger, Florian; Heuser, Michael; Kreipe, Hans; Sotlar, Karl; Engleitner, Thomas; Rad, Roland; Weichert, Wilko; Peschel, Christian; Ruland, Jürgen; Heikenwalder, Mathias; Spiekermann, Karsten; Slotta-Huspenina, Julia; Groß, Olaf; Jost, Philipp J
Abstract:
Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic loss of Ripk3 converted murine FLT3-ITD-driven myeloproliferation into an overt AML by enhancing the accumulation of leukemia-initiating cells (LIC). Failed inflammasome activation and cell death mediated by tumor necrosis factor receptor caused this accumulation of LIC exemplified by accelerated leukemia onset in Il1r1(-...     »
Journal title abbreviation:
Cancer Cell
Year:
2016
Journal volume:
30
Journal issue:
1
Pages contribution:
75-91
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ccell.2016.06.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27411587
Print-ISSN:
1535-6108
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie
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