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Titel:

Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas.

Dokumenttyp:
Journal Article
Autor(en):
Wollny, Damian; Zhao, Sheng; Everlien, Isabelle; Lun, Xiaokang; Brunken, Jan; Brüne, Daniel; Ziebell, Frederik; Tabansky, Inna; Weichert, Wilko; Marciniak-Czochra, Anna; Martin-Villalba, Ana
Abstract:
Acinar cells make up the majority of all cells in the pancreas, yet the source of new acinar cells during homeostasis remains unknown. Using multicolor lineage-tracing and organoid-formation assays, we identified the presence of a progenitor-like acinar cell subpopulation. These cells have long-term self-renewal capacity, albeit in a unipotent fashion. We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells. Transcriptome analysis of single acinar cells reve...     »
Zeitschriftentitel:
Dev Cell
Jahr:
2016
Band / Volume:
39
Heft / Issue:
3
Seitenangaben Beitrag:
289-301
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.devcel.2016.10.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27923766
Print-ISSN:
1534-5807
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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