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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Iversen, Marie B; Reinert, Line S; Thomsen, Martin K; Bagdonaite, Ieva; Nandakumar, Ramya; Cheshenko, Natalia; Prabakaran, Thaneas; Vakhrushev, Sergey Y; Krzyzowska, Malgosha; Kratholm, Sine K; Ruiz-Perez, Fernando; Petersen, Steen V; Goriely, Stanislas; Bibby, Bo Martin; Eriksson, Kristina; Ruland, Jürgen; Thomsen, Allan R; Herold, Betsy C; Wandall, Hans H; Frische, Sebastian; Holm, Christian K; Paludan, Søren R
Title:
An innate antiviral pathway acting before interferons at epithelial surfaces.
Abstract:
Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependen...     »
Journal title abbreviation:
Nat Immunol
Year:
2016
Journal volume:
17
Journal issue:
2
Pages contribution:
150-8
Language:
eng
Fulltext / DOI:
doi:10.1038/ni.3319
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26595890
Print-ISSN:
1529-2908
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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